Novel Roles for Follistatin in Reproductive Biology

Grant number: 606545 | Funding period: 2010 - 2012

Completed

Abstract

The follistatin protein has important functions throughout the body. Recent studies using mutant mice have identified key roles for follistatin in the development and function of the female reproductive system (ovary, uterus). We will now undertake detailed studies to determine how follistatin regulates these processes. This is relevant to our understanding of the mechanisms causing infection and inflammation in the reproductive tract.

Related publications (3)

Follistatin is essential for normal postnatal development and function of mouse oviduct and uterus

SJ Holdsworth-Carson, RG Craythorn, WR Winnall, K Dhaliwal, R Genovese, CJ Nowell, PAW Rogers, DM De Kretser, MP Hedger, JE Girling

2015-01-01

Female mice lacking the follistatin gene but expressing a human follistatin-315 transgene (tghFST315) have reproductive abnormalit..

Expression patterns of activin, inhibin and follistatin variants in the adult male mouse reproductive tract suggest important roles in the epididymis and vas deferens

WR Winnall, H Wu, MA Sarraj, PAW Rogers, DM De Kretser, JE Girling, MP Hedger

2013-03-15

Activin A and its inhibitors follistatin and inhibin play key roles in development and function of the male reproductive tract. Qu..

Progesterone stimulates expression of follistatin splice variants Fst288 and Fst315 in the mouse uterus

RG Craythorn, WR Winnall, F Lederman, EJ Gold, AE O'Connor, DM De Kretser, MP Hedger, PAW Rogers, JE Girling

2012-03-01

Follistatin, an inhibitor of activin A, has key regulatory roles in the female reproductive tract. Follistatin has two splice vari..

University of Melbourne Researchers

Peter Rogers